Activated Vessels are human cultists that have let themselves be overtaken by a demonic presence, distorting them to a dangerous vaguely human-looking creature of great power. Activated Vessels are demons.
These creatures are what Dark Vessels transform into, if they successfully summon a demon into their own bodies. Activated Vessels are mutated, half-demonic things who fight furiously and move very quickly. It's a good idea to kill off the Dark Vessels before they can activate, if at all possible.
Activated vessels have impressive death animations, standing still, shaking, and then shooting out embers of red light, like parts of the demon dispelling into the air.
The spikes that pokes out of their backs are called "Teeth of Diablo", and are indeed a metal spike inserted into the flesh of the willing recipient. The spike does not seem to cause internal haemorrhaging but instead some sort of perverse corruption of both soul and body.
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